Related Works


Various promoter prediction methods have been developed previously for analyzing gene promoter regions. (Table 1). CpGProD identifies CpG islands in mammalian promoter regions (1). DragonGSF predicts gene promoters based on information regarding CpG islands, transcriptional start sites (TSS) and signals downstream of the predicted TSSs (2). NNPP2.2 applied a time-delay neural network for promoter annotation in the Drosophila melanogaster genome (3). Eponine detects the transcriptional initiation site near the TATA box, together with the flanking regions of GC enrichment (4). As to the identification of transcriptional start sites, McPromoter is a statistical method to identify eukaryotic polymerase II TSS in genomic DNA